In January 2024, Diffei Medical took the lead and jointly published a multi-center research paper in the journal Infection (IF=7.5) with the respiratory team of Nanjing Drum Tower Hospital, Eastern Theater Command General Hospital and Jiangsu Provincial Hospital of Integrated Traditional Chinese and Western Medicine.The article included a total of 205 clinical samples from 201 patients with suspected lower respiratory tract infections, performed metagenomic next-generation sequencing (mNGS) and conventional pathogenic tests (CMTs) at the same time, and guided the adjustment of CMTs-negative patients based on the mNGS results. treatment options and evaluate their effectiveness.The study aims to explore the application potential of mNGS in diagnosing suspected lower respiratory tract infections and guiding treatment decisions to prove the feasibility of mNGS in actual clinical scenarios.